|
|
|
|
|
| Research progresses of microRNA in the therapy and prognosis of cardiac arrest |
| Zhai Qiangrong, Ma Qing-bian |
| Department of Emergency, Peking University Third Hospital, Beijing 100191, China |
|
|
|
|
Abstract After the resuscitation, about half of patients could survive without major neurological sequelae nowadays. Despite these advances in resuscitation medicine, other half death and some other survivors have severe neurological impairment. Early prognostication after cardiac arrest could help the health care to be tailored to individual patients. Current biomarkers for prognostication include creatine phosphokinase brain-brain（CK-BB）, NSE and the astroglial protein S100 calcium binding protein B （S100B）. These biomarkers have low sensitivity and the cutoff values are difficult to identify, therefore, they are not recommended for clinical practice. MicroRNAs have recently become the potential biomarker for cardiovascular diseases. Although microRNAs have been extensively studied for myocardial infarc⁃ tion and heart failure as biomarker, less attention has been devoted to their prognostic value after cardiac arrest. Primary research showed microRNAs have important implications for both predicting outcome and treating patients after cardiac arrest. This review highlights recent researches regarding to their prog⁃ nostic and therapeutic value.
|
|
|
|
Corresponding Authors:
Ma Qing-bian, E-mail: maqingbian@medmail.com.cn
|
|
|
|
|
|
|
Address: 1 North 2nd Street,
Zhongguancun, 